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Medicinal Chemistry and Total Synthesis of Bioactive Natural Products. Our most significant work is to Design, Synthesis and Pharmacological Evaluation of Novel benzimidazoles and flavone derivatives as EGFR inhibitors which showing an excellent activity against Non-small cell lung cancer (NSCLC) and breast cancer.

Unravelling the Nucleophilicity of Butenolides for 1,6-Conjugate Addition to p-Quinone Methides: A Direct Access to Diversely Substituted Butenolide-Derived Diarylmethanes Brijesh M. Sharma, Dinesh R. Shinde, Ruchi Jain, Eeshwaraiah Begari, Shruti Satbhaiya, Rajesh G. Gonnade and Pradeep Kumar, Organic Letters, 2018, 20, 2787-2791
"CeCl3.7H2O/NaI-Promoted Regioselective Sulfenylation of Indoles with Sulfonyl Hydrazides" Eeshwaraiah Begari* Nooka Raju Ravi Kiran Reddy Yatra and Pradeep Kumar; Chemistry Selective.,2016, 1, 81-85
Clay supported copper nitrate "Claycop": a mild and eco-friendly reagent for the selective nitration of aromatic olefins. Eeshwaraiah Begari,* Chandani Singh, U. Nookaraju and Pradeep Kumar; Synlett, 2014; 25(14): 1997-2000
Total synthesis of (+)-monocerin via tandem dihydroxylation-SN2 cyclization and copper mediated tandem cyanation-lactonization approach. U.Nookaraju, Eeshwaraiah Begari* and Pradeep Kumar*; Org. Biomol. Chem., 2014, 12, 5973-5980.

Novel benzimidazoles as EGFR inhibitors and their preparation., Pradeep Kumar Tripathi, Jignesh Kantilal Parikh, Eeshwaraiah Begari; US Patent No. US 9862712 B2, Date of grant 09/01/2018.
. Preparation of flavones as EGFR inhibitors and process for preparation thereof., Pradeep Kumar Tripathi, Jignesh Kantilal Parikh, Eeshwaraiah Begari; PCT Int. Appl. (2016), WO 2016125186 A1 20160811
Novel benzimidazoles as EGFR inhibitors and their preparation., Pradeep Kumar Tripathi, Jignesh Kantilal Parikh, Eeshwaraiah Begari; PCT Int. Appl. (2016), WO 2016079763 A1 20160526
"Process for Synthesis of Bis(subtituted-4-Quinolyl)" H. M. Meshram, K. Premalatha, A. V. Madhavi, B. Eshwaraiah and J. S. Yadav; US Patent No: 6777553, Date of grant 17/08/2004
"An improved Synthesis for ?-bromination of sulphonamide substituted Aryl-Alkyl ketones" H. M. Meshram, Y. S. S. Ganesh, A. V. Madhavi, B. Eshwaraiah and J. S. Yadav; Indian patent No: 227731, Date of grant 19/01/2009.
"Process for Synthesis of Bis(subtituted-4-Quinolyl)" H. M. Meshram, K. Premalatha, A. V. Madhavi, B. Eshwaraiah and J. S. Yadav; Japan Patent No: 4394583, Date of grant 23/10/2009.
"Process for Synthesis of Bis(subtituted-4-Quinolyl)" H. M. Meshram, K. Premalatha, A. V. Madhavi, B. Eshwaraiah and J. S. Yadav; Germany Patent No: DE 103 94 213B4, Date of grant 07/12/2006.