Qualifications
Ph.D.
Areas of Interest/Specialization
To develop mechanisms-based diagnostic markers and therapeutics for chronic inflammatory diseases including metabolic disorder-induced diabetic and cardiovascular disorders, cancer, asthma and COPD .
Experience
Associate Professor, School of Life Sciences, Central University of Gujarat, Gandhinagar, India. From July 2017 - till dateAssistant Professor, School of Life Sciences, Central University of Gujarat, Gandhinagar, India. From Oct. 2013 - July 2017..Faculty (Instructor/Asst. Professor), Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA. From Nov 2010 - Oct 2013.Adjunct faculty (Instructor), Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX, USA. From May 2009 - Oct 2013.Post-Doctoral Fellow, Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA. From Oct 2004 - Oct 2010Lecturer, Bio-Engineering research center, RAI International University, New Delhi, India. 2004Senior Research Fellow (SRF), School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. From 2000 - 2003Junior Research Fellow (JRF), School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. From 1998 - 2000.
Awards & Honours
Awarded Ramanujan Fellowship by the department of Science and Technology (DST), Government of India, New Delhi. (2013).Invited Judge at the Medical Student Summer Research Program (MSSRP) Research Poster Session, UTMB, Galveston, TX, USA. (2008-2011).Invited Judge at the Science and Engineering Fair of Galveston sponsored by UTMB, Texas A & M University Galveston and Galveston College, TX, USA. (2009)Invited Judge at the Science Fair at L.A. Morgan School, Galveston, TX, USA. (2009)ARVO Foundation for Eye Research/Retina Research Foundation/ Joseph M. and Eula C. Lawrence Scholarship Travel Grant to attend and present the abstract at the ARVO Annual Meeting, May 6-10, Fort-Lauderdale, FL, USA. (2007).Senior Research Fellowship, University Grants Commission & School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. (2000-2003).Junior Research Fellowship, University Grants Commission (UGC) & School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. (1998- 2000).Awarded Joint CSIR-UGC Junior Research Fellowship in Life Sciences and Eligibility for Lectureship, New Delhi, India. (1998).Awarded Joint CSIR-UGC Junior Research Fellowship in Life Sciences and Eligibility for Lectureship, New Delhi, India. (1997)Merit Cum Mean scholarship, Jawaharlal Nehru University, New Delhi, India. (1995-1997)
Best Peer Reviewed Publications
Agraval H, Yadav UCS*. MMP-2 and MMP-9 mediate cigarette smoke extract-induced epithelial-mesenchymal transition in airway epithelial cells via EGFR/Akt/GSK3β/β-catenin pathway: Amelioration by fisetin. Chem Biol Interact. 2019 Oct 10: 314, 108846. Doi: 10.1016/j.cbi.2019.108846Varghese JF, Patel R, Yadav UCS*. Sterol regulatory element binding protein (SREBP) -1 mediates oxidized low-density lipoprotein (oxLDL) induced macrophage foam cell formation through NLRP3 inflammasome activation. Cellular signalling. 2019 Jan; 53: 316-326. Doi: 10.1016/j.cellsig.2018.10.020.Patel R, Varghese JF, Singh RP, Yadav UCS*. Induction of endothelial dysfunction by oxidized low-density lipoproteins via downregulation of Erk-5/Mef2c/Klf2 signaling: Amelioration by fisetin. Biochimie. 2019 Jun 11; 163: 152-162. DOI: 10.1016/j.biochi.2019.06.007.Singh M, Kumari B, Yadav UCS*. Regulation of oxidized LDL-induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36. Inflamm Res. 2019 Dec;68(12):999-1010. Doi: 10.1007/s00011-019-01281-5.Prasad N, Sharma JR, Yadav UCS. Induction of growth cessation by acacetin via β-catenin pathway and apoptosis by apoptosis inducing factor activation in colorectal carcinoma cells. Mol Biol Rep. 2020;47(2):987-1001. doi:10.1007/s11033-019-05191-xDholia N and Yadav UCS*. Lipid mediator Leukotriene D4-induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway. Prostaglandins Other Lipid Mediat. 2018 May; 136:55-63Varghese JF, Patel R, Yadav UCS*. Novel insights in the metabolic syndrome-induced oxidative stress and inflammation-mediated atherosclerosis. Curr Cardiol Rev. 2018 Mar 14;14(1):4-14..Yadav UC, Srivastava SK. Cysteinyl Leukotrienes (CysLTs): Role in Obesity-Induced Asthma. Curr Mol Med. 2015; 15(7):598-605.Yadav UC, Naura A, Aguilera-Aguirre L, Boldogh I, Boulares HA, Ramana K V, Srivastava SK. Aldose Reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice. PLoS One; 2013; 8(2): e57442.Yadav UC, Srivastava SK, Ramana KV. Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition. J Diabetes Complications. 2012; 26(5):369-77
Recent Peer Reviewed Journals/Books
Free Radicals in Human Health and Disease: Oxidative Stress and Human Health. Yadav UC, Rani V (Eds), Springer (India) Private Ltd., New Delhi, 2015. ISBN 978-81-322-2034-3; DOI 10.1007/978-81-322-2035-0Functional Food and Human Health. Yadav UC and Rani V (Eds), Springer (India) Private Ltd., New Delhi, 2018. ISBN 978-981-13-1122-2; (in press)Invited lead guest editor for a special issue "Oxidative Stress in Metabolic Disorders: Pathogenesis, Prevention, and Therapeutics" of the journal 'Oxidative Medicine and Cellular Longevity' (2015) Hindawi Publishing Corporation.
International Collaboration/Consultancy
Not Available.
Patents (If any)
1. Srivastava, Satish K., Kota V. Ramana, and Umesh Yadav. "Methods for Treating COPD" US 8,785,483 B2, United States Patent & Trademark Office (USPTO) Awarded July 22, 2014